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• Avogadro free 3D cross-platform chemical drawing software

It is the gold standard for chemical drawing software. Plus, it is available in four different versions to meet your specific needs. ChemDraw Products. ChemOffice Professional. The only Research Suite you’ll need. From drawing reactions, to processing instrument data, to structuring experimental data, ChemOffice Professional has you covered. BKChem is a free (as in free software chemical drawing program. BKChem is developed on GNU/Linux. It was however successfully used under WinXP and MacOS X. It was conceived and written by Beda Kosata and is currently maintained by Reinis Danne.

Comment: I had some stability issues w v1.0.3 on OS X but found the software very useful overall. The peptide inserter is a very nice feature. No 2D drawing.

• MarvinSketch free*, mostly 2D chemical drawing software; *educational, also commercial version (Win/Unix/Mac)

Comment: very clean 2D drawing software; structure validation is very useful; specialized features like stereochemistry, complexes, radical, isotopes..; free academic and paid version; v5.10 as of 7/2012.

• ChemDoodle 2D drawing software (Win/Unix/Mac) $60 (2012) review

• ACD/ChemSketch (Win/Linux with emulator) freeware & commercial

• Accelrys Draw (Win only) no-fee educational version & commercial

ISIS/Draw no longer available

successor Symyx, already itself superceded by Accelrys Draw

• XDrawChem free 2D drawing software (Win/Unix/Mac)

Free Molecule Drawing Software Mac Pro

• free Chemistry Development Kit including JChemPaint runs as a browser applet

Comment: simple yet neat little online tool to draw chemical structures

Links

Free Molecule Drawing Software Mac Download

• thorough comparison of chemical drawing software by Tamas Gunda (last updated 2011)
• overview of chemical informatics toolkits by Abhishek Tiwari
• broader comparison of chemical writing, drawing and viewing software by Bob Bruner (last updated 2011)

Free Chemical Drawing Software Mac Os X